The utilization of the large unstained cell (LUC) parameter in lymphoid, haematopoietic and related tissue’s malignant neoplasms
Methods: LUC analysis was performed with Siemens ADVIA® 2120 Hematology System. Data were obtained from Ankara Bilkent City Hospital’s laboratory information system.
Results: A statistical difference in the LUC % data in the case of LUC % <4.5 and LUC % ≥4.5 among preliminary diagnoses was observed (P<0.001). According to the Kruskal-Wallis test, a statistical difference was observed between preliminary diagnosis and LUC % values (P<0.001). The One-way ANOVA test with Bonferroni correction was performed for post hoc multiple comparisons of the preliminary diagnosis among LUC%. LUC% was higher in Hodgkin Lymphoma patients than Myeloid leukaemia patients (P=0.002). LUC % was higher in the Lymphoid leukaemia patients than in the patients with Hodgkin lymphoma (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001). LUC% was higher in patients with leukemia unspecified cell type than Hodgkin lymphoma (P<0.001), Follicular lymphoma (P<0.001), Non-follicular lymphoma (P<0.001), Mature T-Cell and Natural Killer Cell lymphomas (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Malignant immunoproliferative diseases (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001), Lymphoid leukaemia (P<0.001), Myeloid leukaemia (P<0.001), Other leukaemias of specified cell type patients (P<0.001).
Conclusions: The present study underscores the importance of LUC% in line with ICD-10 and may provide ideas for new research. Prospective studies including patient and control groups may be useful in assessing LUC%.
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Article Information
- Article Type Research Article
- Submitted February 21, 2026
- Published July 3, 2025
- Issue Vol. 11 No. 4 (2025)
- Section Research Article
