Distribution of Blood Groups in Patients with Atopic Dermatitis: A Retrospective Case-Control Study
Methods: A retrospective analysis was performed covering a 10-year interval (2014–2024). The study included 3,470 patients diagnosed with atopic dermatitis and 7,449 matched controls, yielding a total sample of 10,919 individuals. Demographic data and blood group characteristics (ABO and Rh typing) were collected and evaluated.
Results: The O Rh– phenotype was observed significantly more often in patients with atopic dermatitis than in controls (5.2% vs. 3.5%; OR=1.52, 95% CI: 1.25–1.85; P<0.001). Conversely, the A Rh– blood group was notably less frequent in atopic dermatitis patients compared with the control group (3.7% vs. 4.7%; OR=0.79, 95% CI: 0.64–0.96; P=0.021).
Conclusions: The findings indicate that the general distribution of ABO and Rh blood groups among patients with atopic dermatitis is comparable to that of healthy individuals. However, the increased prevalence of the O Rh– type and the lower frequency of A Rh– among atopic dermatitis patients suggest that specific blood group antigens may influence susceptibility to atopic dermatitis. Future large-scale, multicenter, and prospective studies are required to further elucidate this potential relationship.
1. Frazier W, Bhardwaj N. Atopic Dermatitis: Diagnosis and Treatment. Am Fam Physician. 2020;101(10):590-598.
2. Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. Allergy Asthma Proc. 2019 Mar 1;40(2):84-92. doi: 10.2500/aap.2019.40.4202.
3. Fishbein AB, Silverberg JI, Wilson EJ, Ong PY. Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection. J Allergy Clin Immunol Pract. 2020;8(1):91-101. doi: 10.1016/j.jaip.2019.06.044.
4. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116-132. doi:10.1016/j.jaad.2014.03.023.
5. Dahalan NH, Tuan Din SA, Mohamad SMB. Association of ABO blood groups with allergic diseases: a scoping review. BMJ Open. 2020;10(2):e029559. doi:10.1136/bmjopen-2019-029559.
6. Sroka-Tomaszewska J, Trzeciak M. Molecular mechanisms of atopic dermatitis pathogenesis. Int J Mol Sci. 2021;22(8):4130. doi:10.3390/ijms22084130.
7. Kuo IH, Carpenter-Mendini A, Yoshida T, et al. Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol. 2013;133(4):988-998. doi:10.1038/jid.2012.437.
8. Gimalova GF, Karunas AS, Fedorova YY, et al. [Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan]. Mol Biol (Mosk). 2014;48(2):265-276. doi: 10.1134/S002689331402006X. [Article in Russian]
9. Song Z, Deng X, Chen W, et al. Toll-like receptor 2 agonist Pam3CSK4 up-regulates FcεRI receptor expression on monocytes from patients with severe extrinsic atopic dermatitis. J Eur Acad Dermatol Venereol. 2015;29(11):2169-2176. doi:10.1111/jdv.13172.
10. Matsunaga MC, Yamauchi PS. IL-4 and IL-13 inhibition in atopic dermatitis. J Drugs Dermatol. 2016;15(8):925-929.
11. Kim KH. Overview of atopic dermatitis. Asia Pac Allergy. 2013;3(2):79-87. doi:10.5415/apallergy.2013.3.2.79.
12. Topno N, Narvey VP, Jain AK. The correlation of allergic rhinitis with ABO phenotype. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 3):1827-1831. doi:10.1007/s12070-017-1215-1.
13. Falsarella N, Ferreira AI, Nakashima F, de Mattos CC, de Mattos LC. Evidence of an association between the O blood group and allergic rhinitis. Rev Bras Hematol Hemoter. 2011;33(6):444-448. doi:10.5581/1516-8484.20110120.
14. Kauffmann F, Frette C, Pham QT, Nafissi S, Bertrand JP, Oriol R. Associations of blood group-related antigens to FEV1, wheezing, and asthma. Am J Respir Crit Care Med. 1996;153(1):76-82. doi:10.1164/ajrccm.153.1.8542166.
15. Chen YL, Chen JC, Lin TM, et al. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan. Clin Exp Allergy. 2005;35(7):926-932. doi:10.1111/j.1365-2222.2005.02278.x.
16. Ronchetti F, Villa MP, Ronchetti R, et al. ABO/secretor genetic complex and susceptibility to asthma in childhood. Eur Respir J. 2001;17(6):1236-1238. doi:10.1183/09031936.01.99109101.
17. Bahashwan AS. The mechanism underlying the association between ABO blood groups and allergic diseases: an evidence-based systematic review. Allergol Immunopathol (Madr). 2025;53(4):78-84. doi:10.15586/aei.v53i4.1287.
18. Ewald DR, Sumner SCJ. Human microbiota, blood group antigens, and disease. Wiley Interdiscip Rev Syst Biol Med. 2018;10(3):e1413. doi:10.1002/wsbm.1413.
19. Altaii HA, Al-Tae FMD. Investigation of serum total IgE and eosinophil levels in different allergic diseases together with the study of their correlations with various possible allergens in Mosul City. Immunol Invest. 2022;51(3):567-587. doi:10.1080/08820139.2020.1853154.
20. Lal T, Sadhasivam M, K SPA, J AAS, R P, Khaleeluddin KB. An observational study to analyse the association of the ABO and Rh blood group systems with bronchial asthma. Cureus. 2023;15(4):e37675. doi:10.7759/cureus.37675.
21. Tamayo-Velasco Á, Peñarrubia Ponce MJ, Álvarez FJ, et al. Can the cytokine profile according to ABO blood groups be related to worse outcome in COVID-19 patients? Yes, they can. Front Immunol. 2021;12:726283. doi:10.3389/fimmu.2021.726283.
22. Abo-Shanab AM, Elnady H, Helwa I, et al. Role of Th2-type cytokines and IgE in asthmatic children. Biomed Pharmacol J. 2020;13(4):1765-1772. doi: 10.13005/bpj/2051.
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Article Information
- Article Type Research Article
- Submitted February 21, 2026
- Published March 1, 2026
- Issue Volume 12 - Issue 3 (March 2026)
- Section Research Article
