Investigation of Prognostic Biomarkers in Advanced Stage Ovarian Cancer
Methods: This study included patients who underwent surgery for advanced-stage ovarian cancer at the Trakya University Gynecology and Obstetrics Clinic between February 2006 and July 2012. Twenty-nine consecutive patients with long-term follow-up were included in the study. Twenty-nine patients with ovarian cancer diagnosed as stage III and stage IV according to International Federation of Gynecology and Obstetrics (FIGO). Twelve healthy postmenopausal patients were also included as a control group. In the study group, all of these patients underwent surgical treatment. Standard surgical treatment for all ovarian cancer patients included total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy as cytoreduction surgery, to minimize residual tumor.
Results: Mean age of the study group was 52.6±8.8 (range: 36-77) years. Twenty-three (79%) were evaluated as stage III, and 6 patients were evaluated as stage IV. The ages of the control group ranged from 49 to 72 (mean: 54.3±8.1 years). The two groups were similar in terms of age (P=0.467). CA-125, transforming growth factor- beta (TGF-β), and C-reactive protein (CRP) values were statistically significantly higher in the patient group (P<0.001, for all variables). Omental involvement was positive in 21 (72%) patients. When patients were evaluated for subdiaphragmatic involvement, subdiaphragmatic peritoneal involvement was detected in 14 (49%) patients. Recurrence was detected in 20 (66%) of the 29 patients included in the study. Recurrence was detected in all 6 patients evaluated as stage IV, for a maximum of 77 months.
Conclusions: Advanced-stage ovarian cancer seems associated with inflammatory markers. We can also suggest that these markers should be considered in patients’ clinical follow-up.
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Article Information
- Article Type Research Article
- Submitted February 21, 2026
- Published March 14, 2026
- Issue 2026: Online First
- Section Research Article
