Online ISSN: 2149-3189
2015
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Nicaea Medical Publishing
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Human papillomavirus causing tonsillar hypertrophy in non-cancerous tonsil

Satvinder Singh Bakshi, Ramiya Kaipuzha, Surianarayanan Gopalakrishnan, Govindarajan A
  • Satvinder Singh Bakshi (Author) Department of Ear, Nose and Throat and Head & Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Pondicherry
  • Ramiya Kaipuzha (Author) Department of Ear, Nose and Throat and Head & Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Pondicherry
  • Surianarayanan Gopalakrishnan (Author) Department of Ear, Nose and Throat and Head & Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Pondicherry
  • Govindarajan A (Author) Department of Ear, Nose and Throat and Head & Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Pondicherry
DOI
https://doi.org/10.18621/eurj.337348
Abstract
Human papillomavirus (HPV) is associated with the development of most anogenital carcinomas, including cervical cancer and, has more recently been suggested to be a risk factor for a subset of head and neck squamous cell carcinoma. A 15-year-old female presented with complaints of chronically progressive pain on swallowing. Examination revealed bilateral Grade III tonsillar enlargement with multiple warty appearances over the surface of the tonsils. She underwent tonsillectomy and histopathologic study revealed tonsillar crypts lined by stratified squamous epithelium with focal koilocytic changes. Polymerase chain reaction study detected HPV 11 DNA. The presence of HPV in the oral cavity and upper respiratory tract mucosa is of great importance, since several studies have demonstrated an association of HPV with a great variety of benign and malignant lesions. A rare case of benign papillomatosis of the tonsil is presented in this study. There is a need for long-term follow-up due to the possibility and risk factors for malignant transformation. 
Keywords
Human papillomavirus, chronic tonsillitis, tonsillectomy, benign papillomatosis
References

[1] Ragin CC, Taioli E, Weissfeld JL, White JS, Rossie KM, Modugno F, et al. 11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours. Br J Cancer 2006;95:1432-8.

[2] Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M, et al. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer 2002;102:152-8.

[3] Ribeiro KM, Alvez JM, Pignatari SS, Weckz LL. Detection of human papilloma virus in the tonsils of children undergoing tonsillectomy. Braz J Infect Dis 2006;10:165-8.

[4] Sisk J, Schweinfurth JM, Wang XT, Chong K. Presence of human papillomavirus DNA in tonsillectomy specimens. Laryngoscope 2006;116:1372-74.

[5] Doorbar J. The papillomavirus life cycle. J Clin Virol 2005;32S:7-15.

[6] Shi N, Lu Q, Zhang J, Li L, Zhang J, Zhang F, et al. Analysis of risk factors for persistent infection of asymptomatic women with high-risk human papilloma virus. Hum Vaccin Immunother 2017;13:1-7.

[7] Syrjanen S. Current concepts on human papillomasvirus infections in children. APMIS 2010;118:494-509.

[8] Palmer E, Newcombe RG, Green AC, Kelly C, Noel Gill O, Hall G, et al. Human papilloma virus infection is rare in nonmalignant tonsil tissue in the UK: implications for tonsil cancer precursor lesions. Int J Cancer 2014;135:2437-43.

[9] Kumaraswamy KL, Vidhya M. Human papilloma virus and oral infections: an update. J Cancer Res Ther 2011;7:120-7.

[10] Molijn A, Kleter B, Quint W, van Doorn LJ. Molecular diagnosis of human papillomavirus (HPV) infections. J Clin Virol 2005;32 Suppl 1:S43-51.

[11] Chen R, Sehr P, Waterboer T, Leivo I, Pawlita M, Vaheri A, et al. Presence of DNA of human papillomavirus 16 but no other types in tumor-free tonsillar tissue. J Clin Microbiol 2005;43:1408-10.

There are 11 references in total.
How to Cite
1.
Bakshi SS, Kaipuzha R, Gopalakrishnan S, A G. Human papillomavirus causing tonsillar hypertrophy in non-cancerous tonsil. Eur Res J. 2017;3(3):269-272. doi:10.18621/eurj.337348
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Vol. 3 No. 3 (2017)

Article Information

  • Article Type Case Report
  • Submitted February 21, 2026
  • Published November 3, 2017
  • Issue Vol. 3 No. 3 (2017)
  • Section Case Report
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