Online ISSN: 2149-3189
2015
Monthly
Nicaea Medical Publishing
Türkiye

Inflammation-related cancer or cancer-related inflammation

Shrihari T.g
  • Shrihari T.g (Author) Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Karnataka
DOI
https://doi.org/10.18621/eurj.312327
Abstract
Inflammation is the body’s defensive action against various stimuli such as physical or chemical or infectious agents. Acute inflammation and their mediators help in tissue repair and healing. If the inflammation aggravates chronically, non-resolved, dysregulated immune system, results release of various inflammatory mediators such as free radicals (ROS and RNS), cytokines, chemokines, growth factors and proteolytic enzymes produced by innate and adaptive immune cells activate transcriptional factors (NF-KB,STAT3 and HIF-1α) results in cell proliferation, angiogenesis, immunosuppression, genetic instability, invasion and metastasis. Oncogenes related to cancer activate inflammatory mediators such as chemokines and cytokines, which alters the inflammatory tumor microenvironment, promotes tumor progression. This article highlights about the role of inflammation and oncogenes activate inflammatory mediators in tumor progression.
Keywords
Inflammation, cancer, lymphocytes, NF-KB, STAT3, myeloid-derived suppressor cells, inflammatory mediators, tumor associated macrophages, tumor associated neutrophils, HIF-1α, oncogenes, cytokines, chemokines, growth factors, COX-2
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How to Cite
1.
T.g S. Inflammation-related cancer or cancer-related inflammation. Eur Res J. 2018;4(1):1-5. doi:10.18621/eurj.312327
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Vol. 4 No. 1 (2018)

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  • Article Type Review
  • Submitted February 21, 2026
  • Published January 3, 2018
  • Issue Vol. 4 No. 1 (2018)
  • Section Review
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