Online ISSN: 2149-3189
2015
Monthly
Nicaea Medical Publishing
Türkiye

Spontaneous ejaculation; caused by venlafaxine, reverted by mirtazapine

Mehmet Camkurt
  • Mehmet Camkurt (Author) Department of Psychiatry, Afsin State Hospital, Kahramanmaras
DOI
https://doi.org/10.18621/eurj.2015.1.3.157
Abstract
Spontaneous ejaculation is a rare side effect of antidepressants. SSRIs, SNRIs, and reboxetine are reported to cause spontaneous ejaculation. Previous reports suggest to stop or change medication in the presence of this side effect, and less is known how to manage patients who want to continue the medication with this side effect. Mirtazapine is a noradrenergic and specific serotonergic antidepressant, mostly used for the treatment of depression. It is recommended as an add-on pharmacotherapy to relieve sexual side effects. Here, we demonstrate a case of spontaneous ejaculation, caused by venlafaxine, and reverted by mirtazapine.
Keywords
Spontaneous ejaculation, management, venlafaxine, mirtazapine
References

Clerc GE, Ruimy P, Verdeau-Pailles J. A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. Int Clin Psychopharmacol. 1994 Sep;9(3):139-43.

Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry. 2001;62(Suppl 3):10–21.

Dording CM, Mischoulon D, Petersen TJ, Kornbluh R, Gordon J, Nierenberg AA, et al. The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. Ann Clin Psychiatry. 2002 Sep;14(3):143–7.

Sivrioglu EY, Topaloglu VC, Sarandol A, Akkaya C, Eker SS, Kirli S. Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition. Prog Neuro-Psychopharmacology Biol Psychiatry. 2007 Mar 30;31(2):548–50.

Yanik M. Spontaneous orgasm started with venlafaxine and continued with citalopram. Can J Psychiatry. 2004 Nov;49(11):786.

Belli H, Aslaner D, Ural C, Vardar MK, Yesilyurt S, Gul ES. Escitalopram related erectile dysfunction and spontaneous ejaculation during micturition. West Indian Med J. 2010 Dec;59(6):715–6.

Gelenberg AJ, Laukes C, McGahuey C, Okayli G, Moreno F, Zentner L, et al. Mirtazapine substitution in SSRI-induced sexual dysfunction. J Clin Psychiatry. 2000 May;61(5):356-60.

Shimojo M, Imai Y, Nakajima K, Mizushima S, Uemura A, Kohsaka S. Interleukin-2 enhances the viability of primary cultured rat neocortical neurons. Neurosci Lett. 1993 Mar 19;151(2):170–3.

Boyarsky BK, Haque W, Rouleau MR, Hirschfeld R. Sexual functioning in depressed outpatients taking mirtazapine. Depress Anxiety. 1999;9(4):175–9.

Oosterhuis I, Heijting L, van Puijenbroek E. Spontaneous ejaculation with the use of noradrenergic reuptake inhibitors. Eur J Clin Pharmacol. 2012 Oct;68(10):1461–2.

O’Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry. 2000 Dec;177:567–8.

Micheal A, Ramana R. Nefazodone-induced spontaneous ejaculation. Br J Psychiatry. 1996 Nov;169(5):672–3.

Wang PW, Wang SY, Huang CJ. Zotepine-induced spontaneous ejaculation. Int J Clin Pharmacol Ther. 2008 Nov;46(11):571–3.

Yoshida K, Higuchi H, Takahashi H, Shimizu T. Ejaculation after defecation without orgasm induced by milnacipran. J Neuropsychiatry Clin Neurosci. 2004 Fall;16(4):544.

Virit O, Savas HA. Citalopram-associated spontaneous ejaculations. J Clin Psychopharmacol. 2008 Jun;28(3):360–1.

Safarinejad MR. Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol. 2007 Oct;27(5):444–50.

Giuliano F, Clément P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol. 2005 Sep;48(3):408–17.

Hellstrom WJG, Sikka SC. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol. 2006 Oct;176(4 Pt 1):1529–33.

Stahl SM. Stahl’s essential psychopharmacology: neuroscientific basis and practical applications. Cambridge University Press; 2013.

There are 19 references in total.
How to Cite
1.
Camkurt M. Spontaneous ejaculation; caused by venlafaxine, reverted by mirtazapine. Eur Res J. 2015;1(3):157-159. doi:10.18621/eurj.2015.1.3.157
License
Creative Commons License

Copyright (c) 2015 The European Research Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

View Vol. 1 No. 3 (2015)

Vol. 1 No. 3 (2015)

Article Information

  • Article Type Case Report
  • Submitted February 21, 2026
  • Published November 3, 2015
  • Issue Vol. 1 No. 3 (2015)
  • Section Case Report
  • File Downloads 1752
  • Abstract Views 900
  • Altmetrics
  • Share
Download data is not yet available.