Online ISSN: 2149-3189
2015
Monthly
Nicaea Medical Publishing
Türkiye

A pregnant woman with primary hyperparathyroidism: a case report

Goknur Yorulmaz, Nur Kebapci, Kevser Onbasi, Belgin Efe, Aysen Akalin
  • Goknur Yorulmaz (Author) Department of Endocrinology and Metabolism, Eskisehir State Hospital, Eskisehir
  • Nur Kebapci (Author) Department of Endocrinology and Metabolism, Osmangazi University Medical School, Eskisehir
  • Kevser Onbasi (Author) Department of Endocrinology and Metabolism, Dumlupinar University Medical School, Evliya Celebi Training and Research Hospital, Kutahya
  • Belgin Efe (Author) Department of Endocrinology and Metabolism, Osmangazi University Medical School, Eskisehir
  • Aysen Akalin (Author) Department of Endocrinology and Metabolism, Osmangazi University Medical School, Eskisehir
DOI
https://doi.org/10.18621/eurj.2016.2.1.77
Abstract
Primary hyperparathyroidism is diagnosed with an increase of calcium levels and a decrease in phosphorus levels. Primary hyperparathyroidism is a rare condition in pregnancy. Calcium levels tend to be low in pregnant women, and high levels of calcium can point a primary hyperparathyroidism. Here, we report an original case of a pregnant woman with primary hyperparathyroidism who was fully healed after the surgery. A 30-year-old pregnant women (10th gestational week), admitted to the endocrinology department for management of thyrotoxicosis, when high calcium levels (11.8 mg/dL) were found in the laboratory tests. The parathyroid hormone level was 135 pg/ml.  Ultrasound imaging revealed a parathyroid adenoma (12x7x27mm). She had maintained high calcium levels despite the medical treatment, for this reason, she had surgery in the second trimester. Our case was diagnosed early due to early recognition of calcium elevation. The mother and the foetus had not any complication. Pregnant women tend to have low calcium levels hence if a hypercalcemia situation appears in pregnant women; primary hyperparathroidism has to be suspected.
Keywords
pregnancy, hypercalcemia, hyperparathyroidism
References

Bringhurst FR, Demay MB, Kronenberg HM.Hormones and disorders of mineral metabolism. In:Williams Textbook Of Endocrinology tenth edition. Philadelphia: Saunders, 2003:1303-73.

Wysolmersky J.J, Insogna KL. The parathyroid glands, hypercalcemia and hypocalcemia. In: Goldman L, Ausiello D. Cecil textbook of medicine 23rd edition. Philadelphia: Saunders, 2008:1897-906.

Breslau NA, Zerwekh JE. Relationship of estrogen and pregnancy to calcium homeostasis in pseudohypoparathyroidism. J Clin Endocrinol Metab. 1986 Jan;62(1):45-51.

Schnatz PF, Curry SL. Primary hyperparathyroidism in pregnancy: evidence-based management. Obstet Gynecol Surv. 2002 Jun;57(6):365-76.

Norman J, Politz D, Politz L. Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss: a call for earlier intervention. Clin Endocrinol (Oxf). 2009 Jul;71(1):104-9.

Carella MJ, Gossain VV. Hyperparathyroidism and pregnancy: case report and review. J Gen Intern Med. 1992 Jul-Aug;7(4):448-53.

Kelly TR. Primary hyperparathyroidism during pregnancy. Surgery. 1991 Dec;110(6):1028-33.

Croom RD 3rd, Thomas CG Jr. Primary hyperparathyroidism during pregnancy. Surgery. 1984 Dec;96(6):1109-18.

Rajala B, Abbasi RA, Hutchinson HT, Taylor T. Acute pancreatitis and primary hyperparathyroidism in pregnancy: treatment of hypercalcemia with magnesium sulfate. Obstet Gynecol. 1987 Sep;70(3 Pt 2):460-2.

Montoro MN, Collea JV, Mestman JH. Management of hyperparathyroidism in pregnancy with oral phosphate therapy. Obstet Gynecol. 1980 Apr;55(4):431-4.

Herrera-Martínez AD, Bahamondes-Opazo R, Palomares-Ortega R, Muñoz-Jiménez C, Gálvez-Moreno MA, Quesada Gómez JM. Primary hyperparathyroidism in pregnancy: a two-case report and literature review. Case Rep Obstet Gynecol. 2015;2015:171828.

Horjus C, Groot I, Telting D, van Setten P, van Sorge A, Kovacs CS, et al. Cinacalcet for hyperparathyroidism in pregnancy and puerperium. J Pediatr Endocrinol Metab. 2009 Aug;22(8):741-9.

Som M, Stroup JS. Primary hyperparathyroidism and pregnancy. Proc (Bayl Univ Med Cent). 2011 Jul;24(3):220-3.

Dochez V, Ducarme G. Primary hyperparathyroidism during pregnancy. Arch Gynecol Obstet. 2015 Feb;291(2):259-63.

There are 14 references in total.
How to Cite
1.
Yorulmaz G, Kebapci N, Onbasi K, Efe B, Akalin A. A pregnant woman with primary hyperparathyroidism: a case report. Eur Res J. 2016;2(1):77-79. doi:10.18621/eurj.2016.2.1.77
License
Creative Commons License

Copyright (c) 2016 The European Research Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

View Vol. 2 No. 1 (2016)

Vol. 2 No. 1 (2016)

Article Information

  • Article Type Case Report
  • Submitted February 21, 2026
  • Published March 3, 2016
  • Issue Vol. 2 No. 1 (2016)
  • Section Case Report
  • File Downloads 1577
  • Abstract Views 1422
  • Altmetrics
  • Share
Download data is not yet available.