The European Research Journal
type: channel
description: The European Research Journal (EuRJ) is an international, independent, double-blind peer-reviewed, Open Access and online publishing journal, which aims to publish papers on all the related areas of basic and clinical medicine.
publisher: Nicaea Medical Publishing
language: en
publication name: The European Research Journal
issn: 2149-3189
items: Global News Exposure and Perinatal Anxiety in Pregnant Women: A Cross-Sectional Study
items: Impact of Visual Awareness of Postoperative Appearance on Functional Recovery After High Tibial Osteotomy: A Retrospective Case-Control Study
items: Beyond the Node Count: Metastatic Lymph Node Ratio as a Prognostic Marker in Locally Advanced Colorectal Cancer
items: Early-Onset Rupture and Cardiac Embolization of an Implantable Venous Port Catheter: A Case Report of Pinch-Off Syndrome
items: Effect of Active Aspiration Drainage System Use on Postoperative Outcomes After Cardiac Surgery
items: Evaluation of Ozone Therapy Effectiveness by the Red Cell Distribution Width/Albumin Ratio
items: https://eurj.org.tr/article/view/1262
items: Endometrioid Carcinoma Metastasis and Minute Pulmonary Meningothelial-Like Nodules in the Lung: A Case Report
items: Predictive Value of First Trimester APRI Score and FIB-4 Index for Gestational Diabetes Mellitus
items: Meeting Abstracts of the 6th Uludag Cardiology Summit, March 26-29, 2026, Bursa, Türkiye
items: Mutation-Associated P53 Immunohistochemical Patterns in Invasive Breast Carcinoma: Clinicopathological Correlations
items: Long-Term Outcomes of Pediatric Intracardiac Masses: Clinical Course and Tumor Behavior in a Single-Center Experience
items: Stepwise Diagnostic Evaluation in Pediatric Epilepsy: Clinical and EEG Predictors of MRI Positivity and Diagnostic Reclassification
items: Outcomes of Single-Level and Multi-Level Thoracoscopic Sympathectomy in Primary Axillary Hyperhidrosis: A Multicenter Retrospective Analysis
items: Analysis of Early Reoperation and Mortality Following Intertrochanteric Fracture Fixation in Elderly Patients: A Focus on Frailty, Bone Quality, and Technical Factors
items: Craniofacial Morphological Features in Childhood Age with Autism Spectrum Disorder
items: Three Decades of SSRI/SNRI Withdrawal Research: A Bibliometric and Science-Mapping Study
items: Chronobiology and Chronotherapy-Related Effects in Non-Traumatic Pain Presentations in the Emergency Department: A Retrospective Study
items: Effects of Localized Arm Fatigue, General Fatigue, and Elbow Bracing on Shooting Accuracy and Shoulder Proprioception: A Randomized Crossover Study
items: Biomechanical Determinants of Shooting Performance: The Role of Wrist and Elbow Joint Range of Motion in Male Basketball Players
items: Biologic Therapies for Type 2 Inflammatory Diseases: A Bibliometric Analysis of Publication Trends and Intellectual Structure
items: Febrile Seizures: Clinical Factors Influencing the Length of Hospital Stay
items: Impact of Comorbidities on Local Anesthetic Hypersensitivity: A Decade of Clinical Experience
items: Comparative Outcomes of Surgery and Chemoradiotherapy After Neoadjuvant Chemotherapy in Stage II–III Bladder Cancer
items: Therapeutic Effects of Alpha-Lipoic Acid on High-Dose Ibuprofen-Induced Renal Damage in Rats
items: Evaluation of Cardiac Functions and Rhythm in Pediatric Patients Diagnosed with Chronic Kidney Failure
items: Cardio-Hematology Crossroads: A Diffuse Large B-Cell Lymphoma Case Presenting with a Cardiac Mass
items: The Effects of Nateglinide and Octreotide on the Uterus in Rats with Experimentally Developed Polycystic Ovary Syndrome: A Histopathological Study
items: The Relationship Between Forward Head Posture with Hand Grip Strength and Thoracic Kyphosis Among Young Adults
items: Factors Affecting Mortality in COVID-19 Pneumonia Patients Treated with Tocilizumab

Global News Exposure and Perinatal Anxiety in Pregnant Women: A Cross-Sectional Study
type: item
description: Objective: This study aimed to investigate the relationship between global news exposure and perinatal anxiety levels among pregnant women. Methods: This cross-sectional analytical study included 180 pregnant women. Data were collected via an online questionnaire consisting of sociodemographic characteristics, global news consumption habits, and the Perinatal Anxiety Screening Scale (PASS). Correlations were assessed using Spearman analysis, and independent predictors were evaluated with multivariate linear regression. Results: A total of 169 participants were included in the final analysis. The mean PASS score was 34.2±15.8. Significant positive correlations were found between anxiety levels and daily news checking frequency (r=0.172, P=0.025), fear of missing news (r=0.154, P=0.046), repetitive checking behavior (r=0.262, P<0.001), post-exposure tension (r=0.236, P=0.002), and perceived impact of negative news on pregnancy (r=0.343, P<0.001). In multivariate analysis, repetitive checking behavior and perceived negative impact remained independent predictors. Conclusion: Global news exposure is significantly associated with perinatal anxiety. This relationship appears to be driven more by behavioral and cognitive responses to news rather than exposure duration.
subject: Research Article
  topic: section
subject: Obstetrics and Gynecology
  topic: category
subject: Psychiatry
  topic: category
subject: Global News
  topic: keywords
subject: Perinatal Anxiety
  topic: keywords
subject: Media Exposure
  topic: keywords
subject: Doomscrolling
  topic: keywords
subject: Mental Health
  topic: keywords
subject: Psychiatry
  topic: subjects
subject: Obstetrics and Gynecology
  topic: subjects
subject: Psychiatry
  topic: disciplines
subject: Obstetrics and Gynecology
  topic: disciplines
creator: Süleyman Güngör
creator: Mehmet Buğrahan Gürcan
creator: Ayşe Rabia Kanbak
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-16
publication date: 2026-05-16
starting page: 1
ending page: 8
doi: 10.18621/eurj.1285

Impact of Visual Awareness of Postoperative Appearance on Functional Recovery After High Tibial Osteotomy: A Retrospective Case-Control Study
type: item
description: Objective: This study aimed to evaluate the impact of visual awareness of preoperative and postoperative leg appearance on patient satisfaction and functional recovery after medial open-wedge high tibial osteotomy (MOWHTO) in patients with varus malalignment. We hypothesized that providing patients with visual feedback of their cosmetic improvement may enhance perceived functional outcomes and overall satisfaction. Methods: A retrospective case-control study was conducted including 57 patients who underwent MOWHTO for varus malalignment between 2019 and 2023. Patients were divided into two groups: Group 1 (n=24), who were shown preoperative and postoperative leg photographs, and Group 2 (n=33), who were not. Functional outcomes were assessed using the Short Form-36 (SF-36) physical and mental scores and Lysholm score. Radiological parameters and joint range of motion were also evaluated preoperatively and at final follow-up. Results: Both groups showed significant postoperative improvements in SF-36 and Lysholm scores (P<0.05). However, Group 1 demonstrated significantly higher postoperative SF-36 physical (P=0.001), SF-36 mental (P=0.001), and Lysholm scores (P=0.002) compared to Group 2. Although radiological parameters and joint range of motion improved significantly in both groups, there were no significant differences between groups. Conclusion: Visual presentation of preoperative and postoperative leg photographs may increase patient awareness of surgical changes and be associated with improved patient-reported outcomes and satisfaction following MOWHTO. Incorporating visual methods into patient education may present a simple approach to influencing postoperative perception.
subject: Research Article
  topic: section
subject: Orthopedics and Traumatology
  topic: category
subject: High Tibial Osteotomy
  topic: keywords
subject: Varus Malalignment
  topic: keywords
subject: Functional Outcomes
  topic: keywords
subject: Patient Satisfaction
  topic: keywords
subject: Visual Feedback
  topic: keywords
subject: Aesthetic Perception
  topic: keywords
subject: Orthopedics and Traumatology
  topic: subjects
subject: Orthopedics and Traumatology
  topic: disciplines
creator: Hünkar Çağdaş Bayrak
creator: Bekir Karagöz
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-04-18
publication date: 2026-04-18
starting page: 1
ending page: 12
doi: 10.18621/eurj.1212

Beyond the Node Count: Metastatic Lymph Node Ratio as a Prognostic Marker in Locally Advanced Colorectal Cancer
type: item
description: Objective: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, and staging based on the number of metastatic nodes may not fully reflect nodal tumor burden. The metastatic lymph node ratio (mLNR) has been proposed as a more informative prognostic marker, but its role in locally advanced CRC is unclear. This study aimed to evaluate the prognostic value of mLNR in patients with locally advanced (T3–T4), non-metastatic CRC and to identify an optimal cut-off for recurrence prediction. Methods: We retrospectively analysed 225 patients with T3–T4, non-metastatic CRC who underwent curative resection between 2015 and 2019. Disease-free survival (DFS) and overall survival (OS) were estimated using Kaplan–Meier analysis. Associations between mLNR, recurrence, stage and survival were examined with standard statistical tests. An optimal mLNR cut-off for recurrence was derived by receiver operating characteristic (ROC) analysis. Results: Patients with recurrence had significantly higher mLNR than recurrence-free patients. mLNR correlated inversely with DFS but not with OS. Higher mLNR was associated with T4 tumors and with higher AJCC stage. ROC analysis identified an mLNR cut-off of 0.1846 (area under the curve 0.643). Patients with mLNR ≥ 0.1846 had significantly shorter DFS and OS. A lymph node yield ≥12 was associated with longer DFS but not OS. Conclusion: mLNR is associated with recurrence, tumor stage and survival in locally advanced CRC, and a threshold around 0.18 may improve risk stratification beyond conventional node counts.
subject: Research Article
  topic: section
subject: General Surgery
  topic: category
subject: Colorectal Cancer
  topic: keywords
subject: Disease-Free Survival
  topic: keywords
subject: Lymph Node Yield
  topic: keywords
subject: Metastatic Lymph Node Ratio
  topic: keywords
subject: Overall Survival
  topic: keywords
subject: General Surgery
  topic: subjects
subject: General Surgery
  topic: disciplines
creator: Yusuf Emre Aytin
creator: Oguzhan Alp Ozturk
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-09
publication date: 2026-05-09
starting page: 1
ending page: 11
doi: 10.18621/eurj.1283

Early-Onset Rupture and Cardiac Embolization of an Implantable Venous Port Catheter: A Case Report of Pinch-Off Syndrome
type: item
description: Implantable venous access devices are indispensable for long-term treatment management in oncology patients; however they may lead to rare but serious mechanical complications. While ''Pinch-off syndrome'' is typically associated with chronic catheter wear occurring over several months, we present the case of a 46-year-old female patient who developed complete rupture and cardiac embolization only 12 days after implantation. The catheter ruptured during the first chemotherapy session, 7 days after placement, and became lodged between the right ventricle and the subclavian vein. The embolized distal fragment was successfully retrieved via the right brachial vein using a snare catheter.
subject: Case Report
  topic: section
subject: Cardiovascular Surgery
  topic: category
subject: Pinch-Off Syndrome
  topic: keywords
subject: Catheter Rupture
  topic: keywords
subject: Cardiac Embolization
  topic: keywords
subject: Snare Catheter Retrieval
  topic: keywords
subject: Costoclavicular Forceps
  topic: keywords
subject: Cardiovascular Surgery
  topic: subjects
subject: Cardiology
  topic: subjects
subject: Cardiovascular Surgery
  topic: disciplines
subject: Cardiology
  topic: disciplines
creator: Mehmet Aslan
creator: Umut Serhat Sanrı
creator: Cemal Köseoğlu
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-08
publication date: 2026-05-08
starting page: 1
ending page: 4
doi: 10.18621/eurj.1274

Effect of Active Aspiration Drainage System Use on Postoperative Outcomes After Cardiac Surgery
type: item
description: Objective: Postoperative drainage systems are essential for maintaining hemodynamic stability and enabling early detection of complications after cardiac surgery. This study aimed to evaluate the impact of an active suction drainage system applying negative pressure on postoperative morbidity and mortality. Methods: This single-center retrospective study included 153 patients who underwent open-heart surgery between August 2023 and August 2024. Patients were divided into two groups based on the drainage method: active suction drainage (n=69) and conventional drainage (n=84). Postoperative drainage volume, cardiac tamponade, re-exploration for bleeding, mortality, and postoperative complications such as acute kidney injury and wound infection were evaluated. Univariate logistic regression analyses were performed to assess potential confounding factors. Results: Cardiopulmonary bypass time, aortic cross-clamp time, and total operative duration were significantly longer in the active suction group (P=0.007, P=0.009 and P=0.010, respectively), while local hemostatic agent use was higher in the conventional group (P<0.001). Despite these differences, postoperative drainage volume, re-exploration rates, incidence of cardiac tamponade, acute kidney injury, wound infection, and mortality were comparable between groups (all P>0.05). Length of hospital stay was significantly longer in the active suction group. Univariate regression analyses did not identify any independent predictors of re-exploration or cardiac tamponade (P>0.05 for all variables). Conclusion: Active suction drainage was not associated with significant differences in major postoperative outcomes compared with conventional drainage methods. Although operative variables differed between groups, these factors did not demonstrate an independent effect on clinical outcomes. A numerically higher incidence of cardiac tamponade in the active suction group did not reach statistical significance and should be interpre…
subject: Research Article
  topic: section
subject: Cardiovascular Surgery
  topic: category
subject: Active Suction System
  topic: keywords
subject: Cardiac Surgery
  topic: keywords
subject: Negative Pressure Drainage
  topic: keywords
subject: Re-Exploration
  topic: keywords
subject: Cardiovascular Surgery
  topic: subjects
subject: Cardiovascular Surgery
  topic: disciplines
creator: Mustafa Can Sofuoğlu
creator: Merve Ateş
creator: Emine Turhan
creator: Muhammet Onur Hanedan
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-18
publication date: 2026-05-18
starting page: 1
ending page: 11
doi: 10.18621/eurj.1273

Evaluation of Ozone Therapy Effectiveness by the Red Cell Distribution Width/Albumin Ratio
type: item
description: Objective: Ozone is an inorganic gas utilized for medical purposes. Ozone therapy has gained increasing popularity in recent years and is employed in the treatment of chronic diseases associated with inflammation. The red cell distribution width/albumin ratio (RAR) has recently emerged as an inflammatory marker. The aim of this study was to evaluate the efficacy of ozone therapy in patients with spinal pain and to investigate the effect of ozone therapy on inflammation through changes in the RAR value. Methods: This prospective pilot study was conducted in a pre- and post-treatment design on patients with spinal pain. In addition to demographic data, visual analog scale (VAS) scores and RAR values were recorded before and after ozone therapy. All patients underwent major ozone autohemotherapy. Data were analyzed using the SPSS software. Results: During the study period, 93 patients presented to the ozone therapy unit. After applying the exclusion criteria, 66 patients were included in the analysis. The mean pre-treatment VAS score was 6.74±1.53, while the mean post-treatment VAS score was 4.08±1.54 (P<0.05). The mean pre-treatment RAR value was 3.37±0.64, which decreased to 3.14±0.50 following ozone therapy (P<0.05). Conclusion: Our findings demonstrate that major ozone autohemotherapy is effective in alleviating spinal pain. Furthermore, the reduction in RAR values before and after treatment indicates that major ozone autohemotherapy exerts an anti-inflammatory effect.
subject: Research Article
  topic: section
subject: Traditional and Complementary Medicine
  topic: category
subject: Family Medicine
  topic: category
subject: Ozone Therapy
  topic: keywords
subject: Red Cell Distribution Width (RDW)
  topic: keywords
subject: RDW/Albumin Ratio
  topic: keywords
subject: Spinal Pain
  topic: keywords
subject: Family Medicine
  topic: subjects
subject: Traditional and Complementary Medicine
  topic: subjects
subject: Family Medicine
  topic: disciplines
subject: Traditional and Complementary Medicine
  topic: disciplines
creator: Meryem Betos Koçak
creator: Mehmet Akif Nas
creator: ideal Beraa Yılmaz Kartal
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-05
publication date: 2026-05-05
starting page: 1
ending page: 8
doi: 10.18621/eurj.1264

https://eurj.org.tr/article/view/1262
type: item
title: The Contribution of Yâdigâr-i Ibn-i Sharif to Orthopedics Through Fifteenth-Century Medical Knowledge: Modern Interpretations of Traditional Therapeutic Practices and an Ethnopharmacological–Orthopedic Analysis
description: This study examines the fifth chapter of Yâdigâr, written by the 15th-century Ottoman physician Tabîb Ibn-i Sharif, within the context of contemporary orthopedics and traumatology. The chapter addresses therapeutic approaches for musculoskeletal conditions, including fractures, dislocations, and contusions. The historical practices described in the text were interpreted in light of current biomedical and ethnopharmacological knowledge, with particular emphasis on herbal formulations and nutritional recommendations. Several of these traditional approaches suggest conceptual parallels with modern scientific understanding, especially regarding anti-inflammatory, antimicrobial, and nutritional effects that may support tissue healing. However, certain practices, such as bloodletting, are inconsistent with current orthopedic principles. Overall, this analysis indicates that historical medical texts such as Yâdigâr may provide conceptual rather than directly clinical relevance, offering valuable insights for ethnopharmacological research and contributing to a broader understanding of the historical development of orthopedic knowledge.
subject: Review
  topic: section
subject: Medical History
  topic: category
subject: Orthopedics and Traumatology
  topic: category
subject: Ottoman Medicine
  topic: keywords
subject: Ethnopharmacology
  topic: keywords
subject: Orthopedics
  topic: keywords
subject: Fifteenth Century
  topic: keywords
subject: Orhtopedics and Traumatology
  topic: subjects
subject: Medical History
  topic: disciplines
subject: Ethnopharmacology
  topic: disciplines
subject: Orthopedics and Traumatology
  topic: disciplines
creator: Yaşar Mahsut Dinçel
creator: Oktay Adanır
creator: Gündüz Ercan Kutluay
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-04-29
publication date: 2026-04-29
starting page: 1
ending page: 8
doi: 10.18621/eurj.1262

Endometrioid Carcinoma Metastasis and Minute Pulmonary Meningothelial-Like Nodules in the Lung: A Case Report
type: item
description: Minute pulmonary meningothelial-like nodules (MPMN) are rare pulmonary lesions characterized by the proliferation of cells showing meningothelial differentiation and are most commonly detected incidentally. Their coexistence with pulmonary metastases is uncommon. We report a case of metastatic endometrioid carcinoma of the lung associated with incidentally identified MPMN. A 60-year-old woman with a history of endometrioid carcinoma presented with a soft tissue density lesion measuring 38×42 mm with ill-defined margins, causing mild narrowing of the right upper lobe bronchus on computed tomography. Surgical resection of the lung mass was performed. Intraoperative frozen section examination revealed a malignant epithelial neoplasm consistent with adenocarcinoma. On permanent sections, histopathological evaluation demonstrated an epithelial tumor composed of complex and cribriform glandular structures within a desmoplastic stroma, accompanied by loss of polarity and nuclear enlargement, consistent with metastatic endometrioid carcinoma. In the wedge resection specimen obtained after frozen section examination, multiple microscopic lesions were identified in the non-neoplastic lung parenchyma. These lesions consisted of bland cells with round to ovoid nuclei arranged in whorled patterns along the alveolar septa. Immunohistochemical analysis supported the diagnoses of metastatic endometrioid carcinoma and MPMN, respectively. Based on the histopathological, immunohistochemical, and clinical findings, the mass lesion was diagnosed as metastatic endometrioid carcinoma, while the incidental parenchymal lesions were diagnosed as MPMN. To our knowledge, coexistence of MPMN with metastatic endometrioid carcinoma is exceedingly rare and not well documented in the indexed English-language literature.
subject: Case Report
  topic: section
subject: Medical Pathology
  topic: category
subject: Endometrioid Carcinoma
  topic: keywords
subject: Minute Pulmonary Meningothelial-Like Nodules
  topic: keywords
subject: Pulmonary Metastases
  topic: keywords
subject: Medical Pathology
  topic: subjects
subject: Medical Pathology
  topic: disciplines
creator: Müberra Konur
creator: Burcu Belen Aydoğmuş
creator: Çiğdem Özdemir
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-18
publication date: 2026-05-18
starting page: 1
ending page: 6
doi: 10.18621/eurj.1257

Predictive Value of First Trimester APRI Score and FIB-4 Index for Gestational Diabetes Mellitus
type: item
description: Objective: Inflammation, liver injury, and subclinical fibrotic processes secondary to insulin resistance are thought to play an important role in gestational diabetes mellitus (GDM). This study aimed to evaluate the predictive value of the aspartate aminotransferase–platelet ratio index (APRI) and fibrosis-4 (FIB-4) index, which reflect inflammatory status and hepatic involvement, for the prediction of GDM. Methods: This retrospective study included 3,305 pregnant women who delivered at Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital between January 2020 and December 2024. Of these, 371 women were diagnosed with GDM, while 2,934 women with normal glucose tolerance constituted the control group. Oral glucose tolerance test results, APRI scores, and FIB-4 indices were compared between the groups. Results: The median APRI score and FIB-4 index were significantly higher in the GDM group than in the control group (P<0.001 and P=0.027, respectively). An APRI score >0.22 predicted GDM with a sensitivity of 61.46% and a specificity of 66.02% (AUC=0.667, P<0.001), whereas a first-trimester FIB-4 index >0.53 showed a sensitivity of 66.31% and a specificity of 41.0% (AUC=0.535, P=0.027). ROC analysis demonstrated that first-trimester APRI had significantly greater predictive ability for GDM than FIB-4 (P<0.001). Correlation analysis revealed no significant associations between APRI and clinical parameters, while the FIB-4 score showed weak positive correlations with age and parity. Conclusion: The present study suggests that both APRI score and FIB-4 index may serve as noninvasive biomarkers for the early prediction of GDM. Notably, the APRI score demonstrated superior predictive performance compared with FIB-4 index. Keywords: Gestational Diabetes Mellitus, APRI Score, FIB-4 Index, Inflammation, Oral Glucose Tolerance Test
subject: Research Article
  topic: section
subject: Obstetrics and Gynecology
  topic: category
subject: Gestational Diabetes Mellitus
  topic: keywords
subject: APRI Score
  topic: keywords
subject: FIB-4 Index
  topic: keywords
subject: Inflammation
  topic: keywords
subject: Oral Glucose Tolerance Test
  topic: keywords
subject: Obstetrics and Gynecology
  topic: subjects
subject: Obstetrics and Gynecology
  topic: disciplines
creator: Şeniz Kurtoğlu Esen
creator: Esra Kartal Golcük
creator: Gülten Özgen
creator: Nergis Kender Ertürk
creator: Burcu Dinçgez
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-14
publication date: 2026-05-14
starting page: 1
ending page: 9
doi: 10.18621/eurj.1261

Meeting Abstracts of the 6th Uludag Cardiology Summit, March 26-29, 2026, Bursa, Türkiye
type: item
description: OP-1. Prognostic Value of the HALP Score for Predicting Left Ventricular Remodeling in STEMI Patients Undergoing Primary PCI OP-2. Short Term Clinical Outcomes and Predictors of Selective Left Bundle Branch Pacing OP-3. Association Between Delayed QRS Transition Zone and Diabetes Mellitus OP-4. Vasospastic Angina: A Case of Coronary Spasm Confirmed by Ergonovine OP-5. Cardiac Effects of Chronic Pyrethroid Exposure OP-6. Effect of SGLT-2 Inhibitors on MPV in Heart Failure Patients OP-7. Evaluation of Subclinical Myocardial Dysfunction in Cirrhosis Using 4D Strain Analysis OP-8. The Role of the Intermountain Risk Score in Predicting Coronary Artery EctasiaOP-9. Association Between Uric Acid to Albumin Ratio and No-Reflow Phenomenon in Patients with NSTEMI OP-9. Association Between Uric Acid to Albumin Ratio and No-Reflow Phenomenon in Patients with NSTEMI OP-10. Coronary Vasospasm Presenting as ST-Elevation Myocardial Infarction: A Case Report OP-11. Management of a Stripped Stent within a Dissected Coronary Lesion OP-12. Prognostic Utility of the Pan-Immune-Inflammation Value (PIV) in Predicting No-Reflow Among Patients Undergoing Primary PCI for STEMI OP-13. VARC-3 Outcomes of Myval, Portico, and Evolut-R in TAVI OP-14. Colchicine Aiding Recurrent Pacemaker Pocket Inflammation Management: A Case Report OP-15. Colchicine Use After Coronary Artery Stenting: One-Year Follow-Up Results OP-16. Drug-Coated Balloon-Only Strategy for Chronic Total Occlusion: A Prospective, Two-Center Study of 48 Patients OP-17. The Role of Pharmacological Cocktails in Preventing Radial Spasm and Complications During Percutaneous Coronary Intervention (PCI): A Clinical Study OP-18. Drug-Coated Balloon-Only Strategy in a True LCx–OM Bifurcation Lesion (Medina 1.1.1): Case Report with 12-Month Follow-Up OP-19. The Utility of Atherogenic Index of Plasma in Predicting in-Hospital Ischemic Stroke in Patients Undergoing Carotid Artery Stenting OP-20. A Case of Long QT Syndrome Presenting with Vent…
subject: Meeting Abstracts
  topic: section
subject: Cardiology
  topic: category
subject: Cardiology
  topic: keywords
subject: Scientific Meeting
  topic: keywords
subject: Arrhythmia
  topic: keywords
subject: Coronary Artery Disease
  topic: keywords
subject: Heart Valve Disease
  topic: keywords
subject: Acute Coronary Syndrome
  topic: keywords
subject: Percutaneous Procedures
  topic: keywords
subject: Hypertension
  topic: keywords
subject: Cardiology
  topic: subjects
subject: Cardiology
  topic: disciplines
subject: Cardiovascular Surgery
  topic: disciplines
creator: 6th Uludag Cardiology Summit
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-03-27
publication date: 2026-03-27
starting page: S1
ending page: S135
doi: 10.18621/eurj.1260

Mutation-Associated P53 Immunohistochemical Patterns in Invasive Breast Carcinoma: Clinicopathological Correlations
type: item
description: Objective: TP53 mutations are the most common genetic changes in human malignancies. Recent studies suggest that specific p53 immunohistochemical staining patterns may reflect underlying TP53 mutations and have prognostic significance. This study aimed to evaluate the predictive and prognostic importance of p53 immunohistochemical staining patterns in invasive breast carcinoma. Methods: A total of 345 patients with invasive breast carcinoma were included in the present study. p53 immunohistochemistry was evaluated and categorized as wild-type, overexpression, null, cytoplasmic or equivocal. Clinicopathological variables were compared statistically. Results: Wild-type p53 staining was observed in 243 (70.4%) cases, whereas abnormal p53 staining were detected in 90 (26.1%) cases. Abnormal p53 expression were associated with a younger patient age (median 48 vs. 52 years, P=0.041), larger tumor size (29 vs. 22 mm, P<0.001), higher histological grade (P<0.001) and higher Ki-67 levels (P<0.001). Hormone receptor negativity was significantly more frequent in tumor with abnormal p53 staining (ER negativity: 63.3% vs. 9.1%; PR negativity: 65.6% vs. 21.0%; both P<0.001). HER2 positivity was also more prevalent in the abnormal p53 group (P<0.001). Triple-negative breast cancer was significantly more prevalent in tumor with abnormal p53 expression 43.3% vs. 6.6%, P<0.001. Additionally, lymph node metastasis was significantly more prevalent in the abnormal p53 group (75.6% vs. 56.8%, P=0.003). Conclusion: Abnormal p53 staining patterns are strongly associated with adverse clinicopathological features and aggressive molecular subtypes in invasive breast carcinoma. These results suggest that p53 staining patterns could be used as a practical surrogate marker to reflect tumor aggressiveness and provide prognostic information in routine pathological evaluations.
subject: Research Article
  topic: section
subject: Medical Pathology
  topic: category
subject: Breast Carcinoma
  topic: keywords
subject: P53 Staining
  topic: keywords
subject: Immunochemistry
  topic: keywords
subject: Mutation
  topic: keywords
subject: Medical Pathology
  topic: subjects
subject: Medical Pathology
  topic: disciplines
creator: Evren Uzun
creator: Elif Büşra Gökçe
creator: İbrahim Taşkum
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-04-24
publication date: 2026-04-24
starting page: 1
ending page: 10
doi: 10.18621/eurj.1258

Long-Term Outcomes of Pediatric Intracardiac Masses: Clinical Course and Tumor Behavior in a Single-Center Experience
type: item
description: Objective: We aimed to evaluate the clinical characteristics, diagnostic pathways, echocardiographic and Holter findings, treatment strategies, and long-term outcomes of children with intracardiac masses, and to explore factors associated with tumor regression. Methods: This retrospective observational study included children with echocardiographically confirmed intracardiac masses followed at a tertiary pediatric cardiology center between January 2010 and January 2022. Demographic and clinical characteristics, tumor features, serial echocardiographic measurements, 24-hour Holter recordings, treatment strategies, and follow-up outcomes were analyzed. Results: A total of 20 patients were included. Rhabdomyoma was the most common tumor type (60%, n=12), followed by fibroma (30%, n=6). Most patients were asymptomatic or mildly symptomatic at presentation (90%, n=18). Clinically significant arrhythmias were observed in 15% (n=3), predominantly in patients with fibromas. Tumor size reduction was observed in 40% (n=8) of patients. All patients diagnosed during the fetal period (15%, n=3) exhibited tumor size reduction; all had rhabdomyomas. Everolimus was administered in 25% (n=5) of patients, with tumor size reduction observed in 80% (n=4) of treated cases; however, this was not statistically significant (P=0.253). Left ventricular systolic function remained preserved in all patients during follow-up. Conclusion: Pediatric intracardiac masses are predominantly benign but show heterogeneous clinical behavior. Tumor regression was more frequent in rhabdomyomas; however, this may reflect tumor type distribution. Arrhythmias were more frequent in fibromas, supporting rhythm surveillance. Everolimus may be considered in selected patients; however, findings should be interpreted with caution due to limited sample size and potential selection bias, and require confirmation in larger studies.
subject: Research Article
  topic: section
subject: Pediatric Cardiology
  topic: category
subject: Pediatric Cardiac Tumors
  topic: keywords
subject: Rhabdomyoma
  topic: keywords
subject: Fibroma
  topic: keywords
subject: Arrhythmia
  topic: keywords
subject: Echocardiography
  topic: keywords
subject: Everolimus
  topic: keywords
subject: Pediatric Cardiology
  topic: subjects
subject: Pediatric Cardiology
  topic: disciplines
creator: Şule Arıcı
creator: Ahmed Mahmud Çırakoğlu
creator: Figen Akalın
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-12
publication date: 2026-05-12
starting page: 1
ending page: 13
doi: 10.18621/eurj.1220

Stepwise Diagnostic Evaluation in Pediatric Epilepsy: Clinical and EEG Predictors of MRI Positivity and Diagnostic Reclassification
type: item
description: Objective: This study aimed to evaluate the predictive value of clinical and electroencephalographic (EEG) findings for identifying epileptogenic structural lesions on cranial magnetic resonance imaging (MRI) in pediatric epilepsy, and to assess the contribution of MRI to diagnostic reclassification. Methods: A total of 207 pediatric patients with a confirmed diagnosis of epilepsy were retrospectively analyzed. The diagnostic workflow was evaluated through a stepwise model integrating clinical assessment, EEG, and MRI. The primary endpoints comprised the MRI positivity rate, defined by the detection of epileptogenic structural lesions, and the diagnostic reclassification rate, defined as any modification in epilepsy type classification or etiological category following the incorporation of EEG and/or MRI findings. Independent predictors of MRI positivity were identified using multivariable logistic regression analysis. Results: Epileptogenic structural lesions were identified in 9.7% of patients. Despite a relatively modest MRI positivity rate, imaging significantly contributed to diagnostic refinement. Among cases with normal EEG findings, MRI revealed structural pathology in 12%. The overall diagnostic reclassification rate following the addition of MRI was 9.7%. In multivariable analysis, focal-onset seizures (OR=2.63), developmental delay (OR=2.91), abnormal neurological examination (OR=3.08), and focal epileptiform EEG activity (OR=2.47) emerged as independent predictors of MRI positivity (all P<0.05). Agreement between EEG and MRI lateralization was moderate (κ=0.60). Conclusion: In pediatric epilepsy, MRI may substantially contribute to etiological classification, particularly in the presence of high-risk clinical and electrophysiological features. These findings support the implementation of a risk-stratified, stepwise diagnostic approach to optimize clinical management.
subject: Research Article
  topic: section
subject: Radiology
  topic: category
subject: Pediatric Neurology
  topic: category
subject: Pediatric epilepsy; Magnetic resonance imaging; Electroencephalography
  topic: keywords
subject: Pediatric Neurology
  topic: subjects
subject: Radiology
  topic: subjects
subject: Pediatric Neurology
  topic: disciplines
subject: Radiology
  topic: disciplines
creator: Adil Aytaç
creator: Emrah Akay
creator: Professor İpek Dokurel Çetin
creator: Mert Bulut
creator: Bahar Yanik Keyik
creator: Erdoğan Bülbül
creator: Gülen Demirpolat
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-14
publication date: 2026-05-14
starting page: 1
ending page: 14
doi: 10.18621/eurj.1214

Outcomes of Single-Level and Multi-Level Thoracoscopic Sympathectomy in Primary Axillary Hyperhidrosis: A Multicenter Retrospective Analysis
type: item
description: Objective: Primary axillary hyperhidrosis is associated with substantial impairment in quality of life, and endoscopic thoracic sympathectomy (ETS) provides definitive treatment in refractory cases. However, the optimal level of sympathetic interruption remains controversial, and evidence directly comparing different surgical levels in axillary disease is limited. This study aimed to compare surgical outcomes among three sympathectomy levels in patients with primary axillary hyperhidrosis. Methods: This retrospective multicenter study included 83 patients who underwent bilateral clip-based thoracoscopic sympathectomy for primary axillary hyperhidrosis between 2009 and 2023. Patients were stratified into three groups: single-level R3 (n=24), single-level R4 (n=35), and multi-level R2–R4 (n=24). The primary outcome was compensatory hyperhidrosis. Secondary outcomes included complete remission, recurrence, postoperative complications, and patient satisfaction. Factors associated with outcomes were evaluated using univariate and multivariate logistic regression analyses. Results: Compensatory hyperhidrosis occurred in 83.3% of patients in the R2–R4 group, compared with 75.0% in the R3 group and 54.3% in the R4 group (P=0.045). Complete remission rates were comparable among groups (54.2%, 41.7%, and 34.3%, respectively; P=0.452). In multivariate analysis, R4 sympathectomy was associated with significantly lower odds ratio (OR) of compensatory hyperhidrosis compared with R2–R4 (OR: 0.25, 95% CI: 0.06–0.97; P=0.044). Recurrence rates did not differ significantly among groups (20.8%, 25.7%, and 12.5%, respectively; P=0.466). Recurrence was the only independent predictor of patient dissatisfaction (OR: 0.12, 95% CI: 0.03–0.44; P=0.001). Conclusion: Single-level R4 sympathectomy appears to provide a favorable balance between treatment efficacy and side-effect profile in primary axillary hyperhidrosis. Multi-level approaches were not associated with improved clinical outcomes …
subject: Research Article
  topic: section
subject: Axillary Hyperhidrosis
  topic: keywords
subject: Endoscopic Thoracic Sympathectomy
  topic: keywords
subject: Compensatory Hyperhidrosis
  topic: keywords
subject: Sympathectomy Level
  topic: keywords
subject: Thoracic Surgery
  topic: subjects
subject: Thoracic Surgery
  topic: disciplines
creator: Erhan Özer
creator: Hayriye Güneş
creator: Teoman Ekim
creator: Hüseyin Melek
creator: Ahmet Sami Bayram
creator: Cengiz Gebitekin
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-04-20
publication date: 2026-04-20
starting page: 1
ending page: 9
doi: 10.18621/eurj.1206

Analysis of Early Reoperation and Mortality Following Intertrochanteric Fracture Fixation in Elderly Patients: A Focus on Frailty, Bone Quality, and Technical Factors
type: item
description: Objectives: Intertrochanteric femur fractures in older adults carry high risks of early complications and mortality. This study aimed to identify independent predictors of early fixation failure and postoperative mortality by integrating patient-, fracture-, and technique-related factors. Methods: This single-center retrospective cohort included 150 patients aged ≥65 years who underwent surgical fixation with a Dynamic Hip Screw (DHS) or Proximal Femoral Nail Antirotation (PFN-A) for the AO Foundation/Orthopaedic Trauma Association (AO/OTA) 31-A intertrochanteric fractures. Evaluated variables included comorbidity burden assessed using the Charlson Comorbidity Index, bone quality assessed using the Singh Index, pre-fracture mobility assessed using the Functional Ambulation Scale, fracture pattern, and reduction–fixation quality. Results: Early reoperation occurred in 12.6% of patients, and 6-month mortality was 24%. Independent predictors of early reoperation included fracture instability (AO/OTA 31-A3; adjusted odds ratio [aOR]=1.41) and higher Charlson Comorbidity Index score (aOR=2.47). In contrast, better bone quality (higher Singh Index; aOR=0.16), superior reduction–fixation quality (aOR=0.12), and higher pre-fracture mobility (aOR=0.75) were protective against reoperation. Early mortality was independently associated with a higher Charlson Comorbidity Index score (aOR=1.74), poorer bone quality (aOR=0.42), and lower pre-fracture mobility (aOR=0.24). Implant type did not significantly influence either outcome. Conclusions: Early fixation failure is primarily influenced by fracture instability, osteoporosis severity, and fixation quality, whereas early mortality reflects comorbidity burden and frailty. Incorporating comorbidity burden, bone quality, and pre-fracture mobility into preoperative assessment may improve risk stratification and guide personalized perioperative management in elderly patients with intertrochanteric femur fractures.
subject: Research Article
  topic: section
subject: Intertrochanteric Femur Fracture
  topic: keywords
subject: Early Reoperation
  topic: keywords
subject: Mortality Predictors
  topic: keywords
subject: Geriatric Trauma
  topic: keywords
subject: Fixation Stability
  topic: keywords
subject: Orthopaedics
  topic: subjects
subject: Orthopedics and Traumatology
  topic: disciplines
creator: Recep Karasu
creator: Namık Şahin
creator: Mustafa Dinç
creator: Hünkar Çağdaş Bayrak
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 272
ending page: 279
doi: 10.18621/eurj.1828923

Craniofacial Morphological Features in Childhood Age with Autism Spectrum Disorder
type: item
description: Objectives: Autism spectrum disorder often exhibits unusual craniofacial morphology, which may indicate underlying neurodevelopmental abnormalities in childhood. This study aimed to investigate the relationship between craniofacial anthropometric measurements, the severity of autism, and language development in children with autism spectrum disorder. Methods: This study included 66 children (50 boys, 16 girls) aged 6–10 years who were diagnosed with autism spectrum disorder. Three-dimensional facial scanning was performed after the removal of glasses, and anthropometric measurements were analyzed in relation to scores on the Gilliam Autism Rating Scale and the Turkish Communication Development Inventory. Results: A significant association was found between increased head circumference and higher autism severity (P=0.035), with larger head size correlating with decreased forehead height, may suggest greater symptom severity in boys. No significant associations were observed in girls. Craniofacial metrics showed no association with language development in either gender. Conclusions: Head circumference and forehead height have been identified as potential craniofacial indicators of autism severity in boys with autism spectrum disorder. These findings highlight the effectiveness of craniofacial phenotyping in clarifying the neurodevelopmental characteristics associated with autism. Future research, utilizing larger and more sex-balanced cohorts, is imperative to clarify these relationships and their potential diagnostic relevance.
subject: Research Article
  topic: section
subject: Autism Spectrum Disorders
  topic: keywords
subject: Craniofacial Morphology
  topic: keywords
subject: Facial Asymmetry
  topic: keywords
subject: Head Circumference
  topic: keywords
subject: Three-Dimensional Facial Scanning
  topic: keywords
subject: Anatomy
  topic: subjects
subject: Anatomy
  topic: disciplines
creator: Fatih Çetinkaya
creator: Hürriyet Çetinok
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 280
ending page: 288
doi: 10.18621/eurj.1831096

Three Decades of SSRI/SNRI Withdrawal Research: A Bibliometric and Science-Mapping Study
type: item
description: Objectives: Selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) are widely prescribed, and growing evidence highlights the clinical and methodological challenges of withdrawal during discontinuation. This study aimed to provide a comprehensive bibliometric map of SSRI/SNRI withdrawal research to clarify production patterns, citation structures, thematic evolution, and global collaboration. Methods: A comprehensive search of the Web of Science Core Collection (1995–2025) identified 652 original articles on SSRI/SNRI withdrawal, discontinuation, or tapering. Records were analyzed using the bibliometrix package in R for performance metrics, co-citation and keyword networks, and country–institution collaboration structures. Results: The corpus comprised 652 documents published in 308 journals, citing 18,957 references, with an annual growth rate of 7.79%. Articles received a mean of 41.6 citations. The Journal of Clinical Psychiatry (22 articles; h=20) and Journal of Clinical Psychopharmacology (18; h=14) were the most influential sources. Highly cited documents ranged from 270 to 730 citations, predominantly from Lancet, Pediatrics, The New England Journal of Medicine, and American Journal of Psychiatry. Keyword frequency was led by “depression” (n=172), “fluoxetine” (n=153), and “antidepressants” (n=152). The United States produced 240 articles (36.8%; 12,904 citations), forming the central hub of the collaboration network. Conclusions: SSRI/SNRI withdrawal research shows concentrated authorship, journal anchoring, and geographically centralized knowledge production, with emerging themes in tapering, pregnancy outcomes, and pharmacogenetics.
subject: Research Article
  topic: section
subject: Selective Serotonin Reuptake Inhibitor (SSRI)
  topic: keywords
subject: Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
  topic: keywords
subject: Withdrawal
  topic: keywords
subject: Discontinuation
  topic: keywords
subject: Tapering
  topic: keywords
subject: Bibliometric
  topic: keywords
subject: Psychiatry
  topic: subjects
subject: Psychiatry
  topic: disciplines
creator: Erdoğdu Akça
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 256
ending page: 271
doi: 10.18621/eurj.1825803

Chronobiology and Chronotherapy-Related Effects in Non-Traumatic Pain Presentations in the Emergency Department: A Retrospective Study
type: item
description: Objectives: Pain is one of the most frequent reasons for emergency department (ED) admissions, yet the chronobiological patterns of pain-related presentations remain insufficiently explored. This study aimed to retrospectively analyze the temporal and seasonal characteristics of non-traumatic pain-related ED visits, with a focus on daily and seasonal variations influenced by circadian rhythms. Methods: This retrospective, descriptive, cross-sectional study included adult patients (≥18 years) who presented to the Afyonkarahisar Health Sciences University Adult ED with non-traumatic pain between January 1, 2023, and December 31, 2023. Cases were identified based on ICD-10 codes for headache (R51, G43, G44), chest pain (R07.1–R07.4), abdominal pain (R10.0–R10.4), and musculoskeletal pain (M54, M79, M25). Demographic data, admission times, diagnostic procedures, treatment initiation, and hospitalization rates were analyzed. Statistical analyses utilized appropriate parametric and non-parametric tests, with significance set at P<0.05. Results: A total of 4524 patients were included (53.9% female; mean age 47.3±21.4 years). Chest pain was the most frequent diagnosis (40%), followed by headache (35.6%), musculoskeletal pain (19.6%), and abdominal pain (4.8%). ED visits peaked in the evening (mode: 21:09) and were least frequent after midnight. Headache admissions were significantly higher in autumn (30.7%), while chest pain was most common in winter (32%). Women more frequently presented with headache and abdominal pain, while men predominantly reported chest and musculoskeletal pain. Conclusions: Non-traumatic pain-related ED visits appeared to follow certain chronobiological patterns with observable sex-related differences. These preliminary findings may contribute to understanding temporal trends in pain-related ED utilization and could serve as a basis for future studies exploring the potential role of chronotherapy in pain management. Validation through larger, multic…
subject: Research Article
  topic: section
subject: Chronobiology
  topic: keywords
subject: Chronotherapy
  topic: keywords
subject: Circadian Rhythm
  topic: keywords
subject: Emergency Department
  topic: keywords
subject: Non-Traumatic Pain
  topic: keywords
subject: Emergency Medicine
  topic: subjects
subject: Pain
  topic: subjects
subject: Emergency Medicine
  topic: disciplines
creator: Jale Akgöl
creator: Şerife Özdinç
creator: Serra Karakoca
creator: Bahar Karya Alkan
creator: Melisa Baş
creator: Berke Üzeyir Gündoğdu
creator: Orhan Başaran
creator: Ferit Suat Çetin
creator: Esra Akkuş
creator: Kaan Tanrıkulu
creator: Zeynep Beyza Kaya
creator: İsmail Şahin
creator: Mert Aras
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 224
ending page: 234
doi: 10.18621/eurj.1725474

Effects of Localized Arm Fatigue, General Fatigue, and Elbow Bracing on Shooting Accuracy and Shoulder Proprioception: A Randomized Crossover Study
type: item
description: Objectives: This study aimed to comparatively investigate the effects of localized arm fatigue, general fatigue, and elbow brace use on proprioceptive accuracy and shooting accuracy in amateur female basketball players. Methods: Fifty-two amateur female basketball players (mean age: 23.08±2.02 years) participated in a randomized crossover study. Participants underwent three experimental conditions: localized arm fatigue, general fatigue, and brace application, each tested on separate days with a 48-hour washout period between sessions. Proprioceptive accuracy was assessed using the Joint Position Sense Error (in degrees), and shooting accuracy was evaluated based on shot success percentage. Fatigue perception was measured using the Borg Rating of Perceived Exertion Scale. Statistical analyses included Friedman and Wilcoxon signed-rank tests with Bonferroni correction for multiple comparisons. Results: Localized arm fatigue significantly decreased shooting accuracy (from 53.16% to 38.83%, P=0.014) and increased proprioceptive error (from 5.40° to 8.65°, P=0.003). General fatigue resulted in a moderate increase in proprioceptive error (from 4.05° to 5.35°, P=0.049) but did not significantly affect shooting accuracy (P=0.090). The use of an elbow brace improved proprioceptive accuracy (error reduction from 5.30° to 3.00°, P=0.035) and marginally enhanced shooting performance (increase from 48.33% to 54.83%, P=0.027). Strong negative correlations were found between proprioceptive degradation and shooting accuracy after localized fatigue (r= –0.787, P<0.001). Conclusions: Localized arm fatigue impairs proprioception and shooting accuracy more severely than general fatigue. Elbow bracing mitigates these impairments, suggesting its use as an intervention to maintain technical performance under fatigue in basketball athletes.
subject: Research Article
  topic: section
subject: Proprioception
  topic: keywords
subject: Localized Fatigue
  topic: keywords
subject: Elbow Brace
  topic: keywords
subject: Shooting Accuracy
  topic: keywords
subject: Basketball
  topic: keywords
subject: Crossover Study
  topic: keywords
subject: Sports Medicine
  topic: subjects
subject: Medical Physiology (Other)
  topic: subjects
subject: Sports Medicine
  topic: disciplines
creator: Ukbe Şırayder
creator: Oğuzhan Yılmaz
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 199
ending page: 209
doi: 10.18621/eurj.1686204

Biomechanical Determinants of Shooting Performance: The Role of Wrist and Elbow Joint Range of Motion in Male Basketball Players
type: item
description: Objectives: The aim of this study is to examine the relationship between wrist and elbow joint range of motion and shooting performance in young male basketball players. Methods: The research was conducted as a cross-sectional correlational study. The study sample consisted of 23 male basketball players residing in Diyarbakır, selected through purposive sampling. The wrist and elbow joint range of motion values, along with shooting performance scores of the athletes, were measured. Frequency analyses were performed, and after confirming the normality of the data distribution, Pearson correlation and multiple regression analyses were conducted. Results: According to the results, strong and significant positive correlations were observed between elbow flexion and pronation and shooting performance. In addition, elbow supination, as well as wrist flexion and extension, also showed statistically significant positive relationships with shooting performance. However, no significant relationship was found between shooting performance and radial deviation, ulnar deviation, or elbow extension. Conclusions: In conclusion, elbow joint range of motion appears to have a significant and determining effect on shooting performance in young male basketball players. In contrast, wrist mobility contributes to shooting performance to a more limited extent and therefore cannot be considered a direct determining parameter.
subject: Research Article
  topic: section
subject: Basketball
  topic: keywords
subject: Shooting Performance
  topic: keywords
subject: Joint Range of Motion
  topic: keywords
subject: Sports Medicine
  topic: subjects
subject: Sports Medicine
  topic: disciplines
creator: Yusuf Gözaçık
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 210
ending page: 223
doi: 10.18621/eurj.1738948

Biologic Therapies for Type 2 Inflammatory Diseases: A Bibliometric Analysis of Publication Trends and Intellectual Structure
type: item
description: Objectives: To comprehensively analyze the scientific literature (2005–2025) on biologic agents for Type 2 inflammatory diseases, including Severe Asthma (SA), Atopic Dermatitis (AD), and chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to identify publication trends, thematic clusters, collaboration networks, and the field's intellectual foundation. Methods: A bibliometric analysis was performed using data from the Web of Science (WoS) Core Collection (retrieved October 27, 2025). VOSviewer software was used to analyze co-occurrence networks (based on Author Keywords) and map collaborations. Results: A total of 7,339 publications were analyzed. A significant acceleration in publishing occurred after 2017. The most productive countries were the USA (n=2,346), Italy (n=1,149), and the UK (n=936). Thematic analysis identified three distinct clusters: AD, SA, and CRSwNP. The intellectual foundation of the field is built upon highly cited phase 3 clinical trials (e.g., mepolizumab, dupilumab, benralizumab) published in top-tier journals (NEJM, The Lancet). Conclusions: The research landscape for Type 2 biologics has grown rapidly since 2017, driven by clinical validation in landmark trials. The field's focus is evolving from demonstrating clinical efficacy toward mechanism-based personalized medicine and biomarker identification.
subject: Research Article
  topic: section
subject: Atopic dermatitis
  topic: keywords
subject: Bibliometrics
  topic: keywords
subject: Biologic therapy
  topic: keywords
subject: CRSwNP
  topic: keywords
subject: Severe asthma
  topic: keywords
subject: Type 2 inflammation
  topic: keywords
subject: Allergy
  topic: subjects
subject: Immunology
  topic: disciplines
subject: Allergy
  topic: disciplines
creator: Mehmet Emin Gerek
creator: Tuğba Önalan
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 235
ending page: 248
doi: 10.18621/eurj.1821314

Febrile Seizures: Clinical Factors Influencing the Length of Hospital Stay
type: item
description: Objectives: This study aimed to identify the clinical factors influencing the length of hospital stay (LOS) in children aged 0–60 months hospitalized with febrile seizures (FS), and to explore potential immunological and psychosocial modulators that may affect hospitalization decisions. Methods: A retrospective observational study was conducted at a tertiary hospital in Karabük, Türkiye, between September 2023 and September 2025. Medical records of patients diagnosed with FS (ICD-10 R56.0) were reviewed using the FONET and e-Nabız systems. Demographic and clinical variables - including age, sex, fever, seizure duration, type (simple/complex), recurrence, infection focus, and presence of seasonal allergic rhinitis (SAR) - were analyzed. Factors associated with LOS were evaluated using multivariable linear regression (P<0.05). Results: A total of 93 children (53.3% male, mean age: 24.6±13.7 months) were included. The mean LOS was 48.2±44.7 hours. Regression analysis showed that recurrence and SAR were associated with shorter LOS (P=0.062 and P=0.065, respectively), while seizure duration and prematurity had no significant effect. Bronchitis, otitis, and tonsillitis were linked to longer stays, whereas acute gastroenteritis and mild upper respiratory infections were linked to shorter ones. Family history was strongly associated with recurrence but not with LOS. Conclusions: Hospital stay in FS is influenced more by immunological and psychosocial dynamics than by traditional demographic factors. The presence of SAR may act as a modulatory condition reducing LOS, possibly through pre-activated immune regulation. Family experience appears to facilitate earlier discharge. Integrating these factors into clinical decision-making may improve resource use and standardize hospitalization criteria.
subject: Research Article
  topic: section
subject: Febrile Seizures
  topic: keywords
subject: Length of Hospital Stay
  topic: keywords
subject: Seasonal Allergic Rhinitis
  topic: keywords
subject: Immune Modulation
  topic: keywords
subject: Infant and Child Health
  topic: subjects
subject: Pediatric Emergency
  topic: subjects
subject: Pediatric Emergency
  topic: disciplines
subject: Infant and Child Health
  topic: disciplines
creator: Yusuf Deniz
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 249
ending page: 255
doi: 10.18621/eurj.1818986

Impact of Comorbidities on Local Anesthetic Hypersensitivity: A Decade of Clinical Experience
type: item
description: Objectives: Clinicians widely utilize local anesthetic (LA) agents in pain management and surgical interventions. Nevertheless, drug hypersensitivity reaction (HR) to their use continue to raise considerable concern among both clinicians and patients. The present study aims to investigate the relationship between local anesthetic hypersensitivity reactions (LA-HRs) and comorbid conditions in patients referred to our clinic. Methods: Clinical data and test results of patients who were referred to our allergy clinic for evaluation of suspected LA-HR were retrospectively reviewed. Skin tests (ST) and subcutaneous provocation tests (SPT) were performed. Results: A total of 200 patients were included in the study. The most common reason for referral was a suspected LA-HR (80%), followed by a history of HR to other drugs with a need for LA use during upcoming procedures (20%). Among 160 patients with suspected LA- HR, only 5.6% demonstrated confirmed hypersensitivity by positive ST and SPT. Of the 40 patients with a history of HR to other drugs, only 2.5% tested positive for LA-HR. A history of comorbidity was present in 70% patients. Patients with suspected LA-HR had a significantly higher prevalence of comorbidities compared to those with HR to other drugs. However, none of the patients who tested positive had a history of comorbidity. Conclusions: Confirmed hypersensitivity risk among patients reporting LA-HR is very low. Although comorbidities were more common among patients reporting LA-HR, none of the patients with confirmed allergy had any comorbidities, underscoring the low confirmed hypersensitivity rate in this population.
subject: Research Article
  topic: section
subject: Local Anesthetics
  topic: keywords
subject: Drug Hypersensitivity Reactions
  topic: keywords
subject: Comorbidity
  topic: keywords
subject: Skin Tests
  topic: keywords
subject: Allergy
  topic: subjects
subject: Allergy
  topic: disciplines
subject: Immunılogy
  topic: disciplines
creator: Mehmet Kılınç
creator: Fatih Çölkesen
creator: Filiz Sadi Aykan
creator: Recep Evcen
creator: Tuğba Önalan
creator: Fatma Arzu Akkuş
creator: Eray Yıldız
creator: Şevket Arslan
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 187
ending page: 198
doi: 10.18621/eurj.1806801

Comparative Outcomes of Surgery and Chemoradiotherapy After Neoadjuvant Chemotherapy in Stage II–III Bladder Cancer
type: item
description: Objectives: Radical cystectomy following neoadjuvant chemotherapy is the standard treatment for Muscle-Invasive Bladder Cancer (MIBC). However, definitive chemoradiotherapy may represent a viable alternative in patients who are medically inoperable or decline surgery. This study aimed to compare the clinical outcomes of patients with stage II–III MIBC treated with neoadjuvant chemotherapy followed by either Radical cystectomy or CRT, the latter performed without maximal transurethral resection of bladder tumor (TURBT). Methods: This retrospective study included 63 patients with stage II–III MIBC treated between December 2014 and March 2025 at two tertiary referral centers in Türkiye. All patients received neoadjuvant chemotherapy (NAC) prior to either surgery (n=39) or Chemoradiotherapy (CRT) (n=24). Clinicopathological, laboratory, and survival data were analyzed. Overall Survival (OS) and Event-Free Survival (EFS) were assessed using the Kaplan–Meier method and compared with the log-rank test. Cox regression was used to identify independent prognostic factors. Results: The median age was 64 years, and 88.9% of patients were male. Comorbidities were more frequent in the CRT group (79.2% vs. 59%), though the difference was not statistically significant (P=0.099). Median OS was 46.5 months in the surgery group and 31.6 months in the CRT group (P=0.407), while median EFS was 30.1 and 21.0 months, respectively (P=0.375). Distant metastasis was the most common recurrence pattern (36.5%). Multivariate analysis identified comorbidity (Hazard ratio [HR] = 0.37, 95% CI: 0.17–0.80, P=0.012) and hemoglobin <12 g/dL (HR =0.53, 95% CI: 0.25–0.94, P=0.048) as independent predictors of poor survival. Conclusions: NAC followed by either surgery or CRT provides comparable long-term disease control in patients with stage II–III MIBC. Although RC remains the gold standard for operable patients, CRT offers an effective curative-intent option for those unfit for surgery—even in the abs…
subject: Research Article
  topic: section
subject: Muscle-Invasive Bladder Cancer
  topic: keywords
subject: Neoadjuvant Chemotherapy
  topic: keywords
subject: Radical Cystectomy
  topic: keywords
subject: Chemoradiotherapy
  topic: keywords
subject: Comorbidity
  topic: keywords
subject: Prognosis
  topic: keywords
subject: Overall Survival
  topic: keywords
subject: Event-Free Survival
  topic: keywords
subject: Cancer Diagnosis
  topic: subjects
subject: Cancer Therapy (Excl. Chemotherapy and Radiation Therapy)
  topic: subjects
subject: Oncology
  topic: disciplines
creator: Doğan Bayram
creator: Öznur Bal
creator: Alper Türkel
creator: Serhat Sekmek
creator: Emre Hafızoğlu
creator: Berkan Karabuga
creator: Mutlu Doğan
creator: Efnan Algın
creator: Doğan Uncu
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 160
ending page: 172
doi: 10.18621/eurj.1807684

Therapeutic Effects of Alpha-Lipoic Acid on High-Dose Ibuprofen-Induced Renal Damage in Rats
type: item
description: Objectives: Nonsteroidal anti-inflammatory drugs, particularly ibuprofen, are commonly used worldwide and can cause nephrotoxicity through prostaglandin inhibition, oxidative stress, and inflammatory activation. This study aimed to investigate the histopathological, fibrotic, and oxidative effects of high-dose ibuprofen administration and to evaluate the therapeutic potential of alpha-lipoic acid) in reversing these changes. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups (n=7): Control, Alpha-lipoic acid (100 mg/kg), Ibuprofen (250 mg/kg), and Ibuprofen+Alpha-lipoic acid. Ibuprofen was administered orally for 21 days, while alpha-lipoic acid was given during the last 7 days. Histopathological changes were evaluated using Hematoxylin & Eosin, Masson’s Trichrome, and Periodic Acid–Schiff staining. Fibrotic and inflammatory markers (TGF-β1, α-SMA, TLR-4) were assessed immunohistochemically. Oxidative stress was evaluated by measuring malondialdehyde levels and superoxide dismutase activity. Results: Ibuprofen administration resulted in significant tubular degeneration, hydropic changes, necrosis, tubular dilatation, and hyperemia. Masson’s Trichrome staining showed a significant increase in collagen deposition, while Periodic Acid-Schiff staining revealed glomerular and tubular basement membrane thickening. Immunohistochemistry demonstrated marked upregulation of TGF-β1, α-SMA, and TLR-4 (P<0.001). Biochemically, malondialdehyde levels were significantly increased (P<0.01) and superoxide dismutase activity was markedly decreased (P<0.001) compared to controls. Alpha-lipoic acid treatment significantly ameliorated these changes, reducing fibrosis and inflammatory marker expression and restoring malondialdehyde and superoxide dismutase levels toward normal (P<0.05). Conclusions: Alpha-lipoic acid exerts renoprotective effects against ibuprofen-induced nephrotoxicity by reducing oxidative stress, modulating fibrotic pathways, and impr…
subject: Research Article
  topic: section
subject: Ibuprofen
  topic: keywords
subject: Alpha-Lipoic Acid
  topic: keywords
subject: Nephrotoxicity
  topic: keywords
subject: Renal Fibrosis
  topic: keywords
subject: Oxidative Stress
  topic: keywords
subject: Nefroloji
  topic: subjects
subject: Pathology
  topic: subjects
creator: Halime Tozak Yıldız
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 149
ending page: 159
doi: 10.18621/eurj.1785523

Evaluation of Cardiac Functions and Rhythm in Pediatric Patients Diagnosed with Chronic Kidney Failure
type: item
description: Objectives: Chronic renal failure (CRF) represents a progressive and irreversible decline in renal function. Among individuals with end-stage renal disease (ESRD), cardiovascular disorders are recognized as the leading contributors to morbidity and mortality. The present study aimed to assess cardiac function in pediatric patients diagnosed with CRF. Methods: This cross-sectional study included 30 pediatric patients with CRF who were under follow-up between October 2018 and August 2019, along with 30 age- and sex-matched healthy controls. The CRF group was further divided into two subgroups according to dialysis status. For all participants, conventional 12-lead electrocardiography was performed, and indices associated with atrial (P-wave dispersion, Pd) and ventricular (QT dispersion, corrected QT dispersion, Tp–e, Tp–e/QT, Tp–e/QTc) arrhythmia risk were recorded. Each subject also underwent a detailed echocardiographic evaluation, including both conventional and tissue Doppler measurements. Results: Anthropometric characteristics and blood pressure values did not significantly differ between the patient and control groups. Apart from an increased mean corrected QT dispersion (QTcd), other electrocardiographic parameters were comparable between groups. Ejection fraction (EF) and fractional shortening (FS) values were lower in CRF patients compared with controls. LV mass index (LVMI) was significantly higher in the dialysis subgroup relative to the control group. Additionally, the myocardial performance index (Tei index) was markedly elevated in CRF patients (P<0.001). Conclusions: These findings underscore the need for comprehensive cardiac evaluation in children with CRF. Nonetheless, larger-scale studies are warranted to confirm and expand upon these observations.
subject: Research Article
  topic: section
subject: Cardiac Functions
  topic: keywords
subject: Child
  topic: keywords
subject: Chronic Renal Failure
  topic: keywords
subject: Echocardiography
  topic: keywords
subject: Electrocardiography
  topic: keywords
subject: Pediatric Cardiology
  topic: subjects
subject: Pediatric Cardiology
  topic: disciplines
creator: Abdullah Akkuş
creator: Fatih Şap
creator: Bülent Ataş
creator: Mehmet Burhan Oflaz
creator: Tamer Baysal
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 173
ending page: 186
doi: 10.18621/eurj.1809664

Cardio-Hematology Crossroads: A Diffuse Large B-Cell Lymphoma Case Presenting with a Cardiac Mass
type: item
description: Cardiac involvement by diffuse large B-cell lymphoma (DLBCL) is a rare clinical entity that often presents with nonspecific symptoms, making early diagnosis particularly challenging. In this context, we report a case that highlights the diagnostic obstacles and the importance of early evaluation. A 58-year-old male presented with dyspnea, malaise, fingertip numbness, weight loss, and shoulder pain. Transthoracic echocardiography revealed a right atrial mass, prompting further assessment. Positron Emission Tomography-Computed Tomography demonstrated increased 18F-FDG (18F-fluorodeoxyglucose) uptake in multiple regions, including the cardiac musculature, raising suspicion for disseminated lymphoproliferative disease. The biopsy of the left superior cervical lymph node confirmed diffuse large B-cell lymphoma. The patient underwent six cycles of chemoimmunotherapy and achieved complete metabolic remission. This case underscores the need to consider lymphoid malignancies in the differential diagnosis of intracardiac masses and persistent cardiac symptoms without an obvious cause. Early use of multimodal imaging and prompt histopathological confirmation are critical for accurate diagnosis and appropriate treatment planning. Rapid initiation of immunochemotherapy may improve clinical outcomes and reduce the risk of severe cardiac complications.
subject: Case Report
  topic: section
subject: Cardiology
  topic: category
subject: Hematology
  topic: category
subject: Diffuse Large B Cell Lymphoma
  topic: keywords
subject: Cardiac Involvement
  topic: keywords
subject: Extranodal Involvement
  topic: keywords
subject: Chemotherapy
  topic: keywords
subject: Haematology
  topic: subjects
subject: Cardiology
  topic: subjects
subject: ​Internal Diseases
  topic: subjects
subject: Clinical Oncology
  topic: subjects
subject: Hematology
  topic: disciplines
subject: Cardiology
  topic: disciplines
creator: Pınar Tunçil
creator: Zeynep Sebla Yiğit
creator: Olgu Erkin Çınar
creator: Leylagül Kaynar
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-01
publication date: 2026-06-01
starting page: 704
ending page: 707
doi: 10.18621/eurj.1844523

The Effects of Nateglinide and Octreotide on the Uterus in Rats with Experimentally Developed Polycystic Ovary Syndrome: A Histopathological Study
type: item
description: Objectives: It was aimed to investigate the histopathological effects of Nateglinide (NG) and Octreotide (OC) on uterine morphology in rats with experimentally induced polycystic ovary syndrome (PCOS). Methods: Forty-two female Sprague-Dawley rats (10-12 weeks old, 340-360 g) were divided into six groups (n=7 per group) as Control, PCOS, PCOS+NG, NG only, PCOS+OC, OC only. PCOS was induced via daily oral administration of Letrozole (1 mg/kg) for 21 days. Treatment groups received NG (oral, 30 days) or OC (intraperitoneal, 0.1 mg/kg/day for 30 days). After the experiment, the uterus tissues of all rats were dissected and subjected to histopathological examinations after histological procedures. Results: Histopathological analysis revealed significant uterine damage in the PCOS group compared to other groups (P<0.01). In contrast, the Control, NG-only, and OC-only groups showed normal uterine architecture with intact epithelium, organized glands, and normal stromal structure and there were no significant differences between related groups (P>0.05). Treatment with NG or OC in PCOS rats led to improved epithelial and glandular morphology and reduced Mast cell density, no evidence of edema, and inflammation was found in the connective tissue of these treated groups, suggesting partial improvement of PCOS-induced uterine pathology (P<0.01). Conclusions: NG and OC treatments ameliorated PCOS-induced uterine histopathological changes, suggesting their potential to improve endometrial morphology. These findings may have implications for therapeutic strategies aimed at enhancing endometrial receptivity and highlighting the importance of addressing endometrial health in therapeutic strategies beyond ovarian treatment in PCOS patients.
subject: Research Article
  topic: section
subject: Polycystic Ovary Syndrome
  topic: keywords
subject: Nateglinide
  topic: keywords
subject: Octreotide
  topic: keywords
subject: Uterus
  topic: keywords
subject: Histopathology
  topic: keywords
subject: Rat
  topic: keywords
subject: Pathology
  topic: subjects
subject: Pathology
  topic: disciplines
creator: Ömür Gülsüm Deniz
creator: Pınar Kırıcı
creator: Ebru Annaç
creator: Selçuk Kaplan
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-02-01
publication date: 2026-02-01
starting page: 139
ending page: 148
doi: 10.18621/eurj.1752916

The Relationship Between Forward Head Posture with Hand Grip Strength and Thoracic Kyphosis Among Young Adults
type: item
description: Objective: Forward head posture (FHP) is a common postural abnormality where the external auditory canal is positioned ahead of the shoulder joint’s plumb line. This study aimed to evaluate FHP’s impact on thoracic kyphosis, hand grip strength, and pinch grip strength in healthy adults. Methods: Ninety-three healthy adults (18–25 years) participated, divided into two groups based on craniovertebral angle (CVA): the FHP group (CVA <45°, n=38) and the control group (CVA >45°, n=55). CVA was measured via photogrammetry. The thoracic kyphosis angle was assessed using the Goniometer Pro app. Hand grip strength was measured with a Jamar dynamometer, and pinch grip strength with a Baseline hydraulic pinch gauge. Results: No significant differences were found between groups in thoracic kyphosis angle, hand grip, or pinch grip strength (P>0.05). CVA showed no significant correlation with these parameters in either group (P>0.05). However, in the FHP group, the thoracic kyphosis angle was significantly correlated with non-dominant hand grip strength (r= -0.324, P=0.047), dominant pinch grip strength (r= -0.350, P=0.031), and non-dominant pinch grip strength (r= -0.394, P=0.014). Conclusion: Hand grip and pinch grip strength were not affected by FHP in asymptomatic young adults. No relationship was found between CVA and thoracic kyphosis. However, individuals with FHP and thoracic kyphosis angles above 40° may experience altered non-dominant hand function, potentially due to kyphotic changes.
subject: Research Article
  topic: section
subject: Orthopedic Prosthesis-Orthotics
  topic: category
subject: Craniovertebral Angle
  topic: keywords
subject: Forward Head Posture
  topic: keywords
subject: Hand Grip Strength
  topic: keywords
subject: Pinch Grip Strength
  topic: keywords
subject: Work and Occupational Diseases
  topic: subjects
subject: Orthopaedics
  topic: subjects
subject: Environmental Health
  topic: subjects
subject: Orthopedics
  topic: disciplines
creator: Yunis Akkaş
creator: Ahmet Gökhan Acar
creator: Serap Alsancak
creator: Senem Güner
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-20
publication date: 2026-05-20
starting page: 770
ending page: 779
doi: 10.18621/eurj.1843712

Factors Affecting Mortality in COVID-19 Pneumonia Patients Treated with Tocilizumab
type: item
description: Objective: Severe COVID-19 pneumonia is often complicated by hyperinflammation and multiorgan failure. Tocilizumab, an interleukin-6 receptor antagonist, has been used to mitigate cytokine storm; however, it’s prognostic impact remains uncertain. Methods: This retrospective cohort study included 43 adult patients with PCR-confirmed COVID-19 pneumonia who received tocilizumab at a tertiary hospital in Turkiye between April and September 2020. Patients were categorized as survivors or non-survivors. Demographic data and laboratory markers were analyzed at baseline, 24 hours, and 7 days post-treatment. Statistical analyses included Mann–Whitney U, Wilcoxon signed-rank, and chi-square tests. Results: Non-survivors were significantly older (mean age: 72.4 vs. 64.9 years, P=0.046) and had higher levels of C-reactive protein (P=0.002), D-dimer (P=0.004), procalcitonin (P= 0.001), troponin (P=0.004), BUN (P<0.001) and creatinine (P=0.02). Survivors showed higher albumin and prognostic nutritional index (PNI) values (P=0.009 and P<0.001, respectively). On day 7, survivors exhibited increased lymphocyte, eosinophil, and platelet counts, while non-survivors had persistent neutrophilia, leukocytosis, and elevated neutrophil-to-lymphocyte ratios (P<0.05). Dynamic biomarker trends suggested ongoing inflammation and prothrombotic states among non-survivors. Conclusion: Tocilizumab therapy may be more effective when administered early and in patients with preserved nutritional and immune function. Advanced age, renal dysfunction, elevated inflammatory markers, and poor nutritional status were significant predictors of mortality. Further prospective studies are warranted to validate these findings.
subject: Research Article
  topic: section
subject: Chest Diseases
  topic: category
subject: COVID-19
  topic: keywords
subject: Viral Pneumonia
  topic: keywords
subject: Tocilizumab
  topic: keywords
subject: Prognosis
  topic: keywords
subject: Mortality
  topic: keywords
subject: Chest Diseases
  topic: subjects
subject: Chest Diseases
  topic: disciplines
creator: Selda Günaydın
creator: Hayriye Bektaş Aksoy
creator: İskender Aksoy
creator: Abdülbaki Elmas
creator: Ahmet Cumhur Dülger
rights: Copyright (c) 2026 The European Research Journal https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-05-20
publication date: 2026-05-20
starting page: 780
ending page: 788
doi: 10.18621/eurj.1829791